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Vitamin D and Heart Disease Lebanon MO

New research points to the possibility of a genetic link between vitamin D and heart disease. People with high blood pressure who had a gene variant that reduces vitamin D activation in the body were found to be twice as likely as those without the variant to have congestive heart failure, the study found.

Sudhir K Jain, MD
(314) 894-4900
11124 S Towne Sq
Saint Louis, MO
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Washington University Division of Cardiology
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Cardiology

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Jane Chen, MD
(314) 454-7834
Campus Box 8086 660 S Euclid Ave
Saint Louis, MO
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Cardiology
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Medical School: Washington Univ Sch Of Med, St Louis Mo 63110
Graduation Year: 1993

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Mario Campos Trindade, MD
(636) 916-8200
1301 Boones Lick Rd
Saint Charles, MO
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Medical School: Univ Fed De Rio De Janeiro, Fac De Med, Rio De Janeiro, Rj, Brazil
Graduation Year: 1967

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Ben Dee Mc Callister, MD
(816) 932-5742
4401 Wornall Rd
Kansas City, MO
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Cardiology
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Medical School: Univ Of Ks Sch Of Med, Kansas City Ks 66103
Graduation Year: 1957

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Jerome Valentine Dwyer, MD
(314) 432-3214
3009 N Ballas Rd Ste 264C
Saint Louis, MO
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Medical School: St Louis Univ Sch Of Med, St Louis Mo 63104
Graduation Year: 1985

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John R Raabe, MD
(314) 965-3032
13358 Manchester Rd
Saint Louis, MO
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Optima Heartcare Inc
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Cardiology

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James Aaron Grantham
(816) 931-1883
4330 Wornall Rd
Kansas City, MO
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Cardiology, Internal Medicine

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Brian A Seeck
(636) 239-2711
901 Patients First Dr
Washington, MO
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Cardiovascular Disease

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Daniel B Bauwens
(314) 576-5023
232 S Woods Mill Rd
Chesterfield, MO
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Cardiology, Internal Medicine, Cardiovascular Disease

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Vinod K Raxwal
(913) 588-6015
4801 E Linwood Blvd
Kansas City, MO
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Vitamin D and Heart Disease

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THURSDAY, Dec. 3 (HealthDay News) -- New research points to the possibility of a genetic link between vitamin D and heart disease.

People with high blood pressure who had a gene variant that reduces vitamin D activation in the body were found to be twice as likely as those without the variant to have congestive heart failure, the study found.

The finding may lead to a way to identify people at increased risk for heart disease, according to Robert U. Simpson, an assistant professor of pharmacology at the University of Michigan Medical School and his research colleagues.

They analyzed the genetic profiles of 617 people. One-third had hypertension, one-third had hypertension and congestive heart failure, and the remaining third served as healthy controls.

The researchers found that a variant in the CYP27B1 gene was associated with congestive heart failure in people with hypertension. The study is in the November issue of Pharmacogenomics.

Previous research showed that mutations that inactivate the gene reduce the conversion of vitamin D into an active hormone.

"This study is the first indication of a genetic link between vitamin D action and heart disease," Simpson said in a news release from the University of Michigan.

"If subsequent studies confirm this finding and demonstrate a mechanism, this means that, in the future, we may be able to screen earlier for those most vulnerable and slow the progress of the disease," he added.

More information

The American Heart Association has more about congestive heart failure.

SOURCE: University of Michigan, news release, Dec. 1, 2009

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